Why we chose powders over capsules or tablets

Why we chose powders over capsules or tablets

When In the early stages of Actively Nourish development there was a lot of research into reducing toxic load and there was always the end game result of getting the most benefit out of a product with the following considerations in mind: 

  • bioavailability of each ingredient used
  • Prohibition percentage if capsulation or tablet form where to be the means of dosage 
  • Negative vs positive in mode of consumption

After we looked and asked ourselves these questions it was easy for us to determine that to achieve the ethics of the company and also products we needed ONLY of benefit to the body ingredients. When it comes to freeze dried powders the nutrient and cellular structure of the fruit and veg alongside the adaptogenic herbs 

Was not impacted and once consumed the full absorption and bioavailability of the nutrients, vitamins and minerals were still there. 

Why we didn’t choose to use capsule or tablet forms was simply due to the need for excipients when manufacturing. Excipients were needed to stabilise ingredients when placed under pressure or formed into tablet form. It was these same excipients that can and do interact with the nutritional medicinal productivity of the herbs and also the produce used. 

Excipients come in numerous forms and legally don’t need to label quantities of excipients used when manufacturing the capsules or tablets which leaves uncertainty of the exact “medicinal or nutritional” ingredients within each capsule. A variable and concern for us when thinking of complete benefit to the products and also consumers. 

Below I have outlined what excipients are and how they are used so that you can become aware of them when you check labels on any medicine and also supplement you take. Because knowledge is powerful and it has always been one of our key ethics to share knowledge so that you can become empowered within your own health and health journey. 

Excipients aid in the manufacturing process to help stabilize products so they can be taken in various dosage forms. Often, the active component of a drug or vitamin cannot be manufactured and put into a tablet or capsule form without a stabilizing agent to help keep it active. There are several different types of excipients and fillers used in nutraceutical and pharmaceutical products. Some of the most common include: 

Anti-adherents are the most common anti-adherent used in manufacturing magnesium stearate. It is used to prevent products from sticking or adhering to machines in the manufacturing plant, thereby decreasing waste and increasing profitability for companies.

Binders are used to hold ingredients together. They also give weight and allow small active ingredients to be combined into an easy to take capsule or tablet. Binders are typically a sugar derivative and include: lactose, sucrose, microcrystalline cellulose, maltitol, sorbitol, xylitol etc.

Coatings are added to tablets to help make large, difficult to swallow pills easier to take. They also prevent deterioration from water and moisture. Coatings can also allow for breakdown in a specific organ in the body. For example enteric coatings allow for breakdown in the small intestine, preventing breakdown in the acidic environment of the stomach. Examples include: hydroxypropyl methylcellulose (HPMC).

Disintegrants allow for breakdown of a capsule or tablet when wet. This ensures rapid breakdown to facilitate rapid absorption of a product. Examples include: sodium starch glycolate.

Fillers and diluents add bulk to products making very small active components easy for consumers to take. Examples include: lactose, sucrose, magnesium stearate, glucose, plant cellulose, calcium carbonate etc.

Lubricants prevent the clumping of active ingredients and prevent the sticking of materials to machines in the manufacturing plant. Examples include: silica, talc, stearic acid, magnesium stearate etc.

Preservatives are used to extend the shelf-life of products and prevent degradation, oxidation, bacterial growth etc. Examples include: vitamin A, C, E, selenium, amino acids, methyl paraben, propylparaben

Artificial flavours are artificial flavouring agents added to various pharmaceutical and nutraceutical products to help make certain powdered or liquid medications more palatable. They are labelled as artificial flavours on product labels. There are over 2000 chemicals used to make a wide range of flavours.


The major concern with the use of some excipients and fillers in nutraceuticals ( Natural Health supplements ) and pharmaceuticals is their ability to interact with the medicinal ingredients, hence influencing the reliability of products. With chemical and physical interactions occurring within a supplement it is difficult to determine the exact efficacy of the product remaining. Interactions can render the active ingredient less active and make it less bioavailable (less available for the body to use).

Limited research to determine the impact of long-term use of excipients on health.

Companies are also not required to list the exact amount of fillers within the supplement; therefore it is difficult to determine the amount of non-medicinal ingredients versus medicinal ingredients.


Listed below is a list of adverse health effects associated with specific excipients:

Magnesium stearate: Is a widely used excipient in nutraceutical and pharmaceutical products. Some studies have shown that it suppresses immune function. The absorbability of products is also questionable when magnesium stearate has been added to a formula. As a powerful binder of active constituents the rate of dissolution of a substance is altered, yet studies have shown that bioavailability remains the same. Some manufacturers believe that this is true and will only use magnesium stearate in the formulas as filler and never as coating due to the question of dissolution. Magnesium stearate is naturally produced when soap and hard water mix creating the unwanted “soap scum” ring around bathtubs.[2]

Titanium dioxide: Is a common whitening agent used in some supplements and pharmaceutical agents. It has shown to be a potential carcinogen to humans. Rats studies have shown that inhalation of ultrafine titanium dioxide can cause respiratory tract cancer.[3] [4]

Silica: Is an abundant mineral in the earth’s crust. Is found in nature as sand or quartz and is a flowing agent used in supplements. When inhaled it has been shown to cause auto-immune dysfunction. Inhalation has also been shown to cause lung cancer. However, oral ingestion of silica has not been shown to be non-toxic and is believed to enter and lead the digestive tract via the feces unchanged. Silica is found in certain vegetables, fruits, whole grains and seafood. A clear biological function of silica has not been established; however it may have some benefit in bone and collagen formation and aid skin and nail health. Silica can be found in supplements in the form of silica or silicon dioxide.[5]

Parabens: Are a group of widely used preservative and antimicrobial agents in personal care products and supplements. There is growing concern that parabens can cause hormone disruptions and they have been found in high concentrations in breast cancer tumours. Parabens can be found in supplements as methylparabens, ethylparaben, propylparaben, butylparaben. Choose supplements that avoid this potentially harmful substance.[6]

Lactose: A sugar found in milk can cause severe gastro-intestinal upset in individuals sensitive to milk products. In non sensitive individual’s lactose is generally not a great concern.

Maltodextrin: Is a polysaccharide that is rapidly converted to glucose in the bloodstream. Maltodextrin can come from a variety of starch products. Wheat and corn are the most common. Although not generally a concern in supplements, the source of maltodextrin should be noted. If from a wheat source, gluten will be removed, but should still be avoided in individuals with celiac disease to avoid any potential adverse reaction.

MSG: or Monosodium glutamate is a common flavouring agent in supplements. It is a known neurotoxic agent and should be strictly avoided when choosing supplements. It has also been shown to cross the placenta and induce neuronal damage in developing mice.[7]MSG is a food additive used to enhance the flavour of food. Reactions to MSG may occur and may include: tingling and weakness around the face, temple, upper back, neck, and arms, with flushing of the skin and warmth. Some people experience heart palpitations, intense thirst, anxiety, nausea, and vomiting.

Talc: Is a known carcinogenic. Studies have shown that it increases the risk of endometrial cancer in peri-menopausal women when used topically in the peri-anal area. Inhalant or intravenous talc exposure increases the risk of pulmonary toxicity. Intravenous talc can lead to various degrees of granulomatous formation, compromised pulmonary function or death. The use of talc should be strictly avoided in supplements, oral, inhaled and topical.[8] [9]

Microcrystalline cellulose: Is a bulking agent used in supplements to fill capsules when the medicinal agents are too small. It is an ideal filler as it is naturally occurring and derived primarily from wood pulp. It is glucose units bound together by a beta 1-4 linkage which creates cellulose, a fibre indigestible to humans. It enters and leaves the digestive tract unchanged and is chemically inert.

Gelatin: Is derived from collagen in animal’s skin and bones. It is a gelling agent used in supplements to help coat the outside of capsules to make them easier to swallow. Gelatin is commonly found in various desserts and gummy candies. A vegan alternative to a gelatin capsule is hypromellose.

Gellan gum: Is commonly used as a food additive, it is used in most soy drinks to help keep soy products in suspension. It is used as a thickener and stabilizer in supplements. A study examined the dietary effects of large quantities of gellan gum and found that it seemed to affect transit time by either increasing or decreasing time in a few subjects. Serum cholesterol levels were decreased by an average of 12% in males and 13% in females. No adverse physiological effects were seen in the subjects.[10]

Tartrazine: A yellow colouring agent used in some supplements and pharmaceuticals has been shown to cause adverse reactions in certain individuals. It is well known to cause asthma and urticaria in sensitive individuals and has been shown to cause behavioral changes such as irritability, restlessness, and sleep disturbance in children. The use of any food colouring additive should be strictly avoided when choosing supplements.[11]

Allura Red: A red colouring agent used as a food additive has been linked to both behavioural and physical toxicity. When fed to rats in animal studies, rats displayed significantly reduced reproductive success, weight, brain weight, survival and impaired female vaginal patency development. Behaviourally, the rats had significantly decreased running wheel activity when compared to control.[12]

Indigotine: A blue food colouring agent has been linked to asthma in one study. A case report outlined increased cough, dyspnea, wheezing and nasal congestion in a subject immediately following exposure to indigotine at work.

Brilliant Blue FCF and Indigotine: Two blue food colouring agents have been linked to various adverse effects. Animal studies looked at the adverse effects of brilliant blue and indigotine given to rats over a two year span. The study found that growth inhibition occurred in the male animals fed indigotine and subcutaneous injections of 30 mg of brilliant blue or 20 mg of indigotine into rats weekly for two years produced fibrosarcomas at the site of injection.[13] [14]

Combination of all food colourings: Was tested to determine if adverse effects exist. A study looked at a combination of several food colouring additives and a common preservative, sodium benzoate. This study tested children aged 3 and 8-9 to determine if food colouring additives can increase hyperactivity in children. The study found that food colouring additives or sodium benzoate (or both) increased hyperactivity in both age groups studied. The use of food colouring should be avoided in pharmaceutical and nutraceutical products.

Artificial Flavours: Dr. Ben Feingold an allergist proposed 30 years ago that artificial flavours, colors and salicylates can be the cause of hyperactivity in children. A diet free of artificial colors, flavours and salicylates reduced hyperactivity symptoms and behavioural disturbances in 30 to 50% of children. Other adverse effects noted from the ingestion of artificial flavours and coloring include:[15] [16]

Respiratory: Rhinitis, nasal polyps, cough, laryngeal edema, hoarseness, asthma.

Skin: Pruritus, dermatographia, localized skin lesions, urticaria, angioedema.

Gastrointestinal: Macroglossia, flatulence, constipation, buccal chancres.

Neurological: Headaches, behavioural disturbances.

Skeletal system: arthralgia with edema.

When choosing supplements it is important to talk to your clinical  Naturopathic practitioner about good quality, professional brand products that avoid the use of harmful excipients and fillers. This will prevent any adverse effects, but also will enhance therapeutic response as bioavailability of products will not be affected.

Jump up ↑ Crowley PM (2001) Drug-Excipient Interactions. Pharmaceutical Technology.
Jump up ↑ Tebbey, P. B. (1990). Molecular basis for the immunosuppressive action of stearic acid on T cells. Immunology , 379-84.
Jump up ↑ Titanium Dioxide Classified as Possibly Carcinogenic to Humans. (2006, August). Retrieved November 17, 2010, from Canadian Centre for occupational Health and Safety: http://www.ccohs.ca/headlines/text186.html
Jump up ↑ : Titanium Dioxide Classified as Possibly Carcinogenic to Humans. (2006, August). Retrieved November 17, 2010, from Canadian Centre for occupational Health and Safety: http://www.ccohs.ca/headlines/text186.html
Jump up ↑ Otsuki, T. M. (2007). Immunological Effects of Silica and Asbestos. Cellular and Molecular Immunology , 261-8.
Jump up ↑ Pugazhendh, D. P. (2005). Oestrogenic activity of p-hydroxybenzoic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines. J Appl Toxicol., 301-9.
Jump up ↑ Gao, J. W. (1994). Transplacental neurotoxic effects of monosodium glutamate on structures and functions of specific brain areas of filial mice. Sheng Li Xue Bao. , 44-52.
Jump up ↑ Karageorgi S, G. M. (2010). Perineal use of talcum powder and endometrial cancer risk. Cancer Epidemiol Biomarkers Prev., 1269-75.
Jump up ↑ Hollinger, M. (1990). Pulmonary toxicity of inhaled and intravenous talc. Toxicol Lett., 117-9.
Jump up ↑ Anderson, D. B. (1988). The dietary effects of gellan gum in humans. Food addit contamin , 237-49.
Jump up ↑ Rowe, K. (1994). Synthetic food coloring and behavior: A dose response effect in a double-blind, placebo-controlled, repeated-measures study. Journal of Pediatrics , 691-98.
Jump up ↑ Vorhees, C. B. (1983). Developmental toxicity and psychotoxicity of FD and C red dye No. 40 (allura red AC) in rats. Toxicology , 207-17.
Jump up ↑ Miller, M. L. (1996). Occupational asthma caused by FD&C blue dye no.2. Allergy Asthma Proc., 31-4.
Jump up ↑ Hansenb, W. F. (1966). Chronic toxicity of two food colors, Brilliant Blue FCF and Indigotine. Toxicology and Applied Pharmacology, 29-36.
Jump up ↑ McCann, D. B. (2007). Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised,double-blinded, placebo-controlled trial. The Lancet.
Jump up ↑ Feingold, B. (1976). Hyperkinesis and Learning Disabilities linked to the ingestion of Artificial Food Colors and Flavors. Journal of Learning Disabilities, 551-9.

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